To have a good expected value for the knuckleball then one must have a high expected frequency of throwing a knuckleball.
Back in 2010 Red-Sox flame thrower Daniel Bard, who was top five in average fast ball velocity, performed far better when following Knucleballer Tim Wakefield. This is because Wakefield threw a very slow knuckleball. The change in speed, going from the slowest pitch in MLB to one of the fastest, improved the efficacy of Bard's repertoire. Proof of how effective the change of speed is: the most valuable fastball in 2009 belonged to Tim Wakefield.
Just something to think of before game one of the NBA finals.